Speech read on your trial’s own scale, and a check of every recorded rating interview
A low-cost way to add another layer of sensitivity and specificity: speech read from recordings your trials already hold, site-visit recordings or home sessions, recalibrated when phones change, with every recorded rating interview checked.
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Built for regulated clinical trials
Speech readings on your scale
Each reading sits on the scale your protocol already carries, joined to the visit score, as an exploratory or secondary endpoint fixed in a written analysis plan (SAP or SAP addendum) before post‑baseline recordings are read.
See speech biomarkersEvery recorded interview checked
Screening interviews are read as they arrive, so a flag can reach your blinded team before randomization. Cephalgo never changes a score.
See Trial QCWhy speech
Speech carries motor, cognitive and psychiatric signs
Speaking uses the brain, breathing, the voice box and the muscles of the mouth together, so one short session can hold all of these signs.
More readings per participant
Existing and site-visit recordings add a reading at each visit; home sessions add readings between visits. In dose-finding, each arm gets more readings before the dose decision, unblinded view only.
Nothing to wear
Speech comes through your eCOA or app vendor, a phone call, or our own capture where none exists. No wearable to ship or charge, and no extra site visit.
State of the art, and no black box
Named voice and language features behind every reading. The reference model is calibrated on your screening and baseline ratings, blind to arm, and locked before post‑baseline recordings are read. For your statistician ›
Why Cephalgo
Another layer of sensitivity and specificity, at low cost
No new hardware and no new scale, and your eCOA vendor stays.
A reading on your trial’s own scale at every recorded visit; home sessions add readings between scheduled visits, so a change in grade can show between them.
How a reading is made SpecificityRecalibration keeps a phone or software change from reading as disease change. Trial QC flags rater drift in recorded interviews.
Device changes Value from audio you holdRe‑analysis of a completed or ongoing trial’s audio, with no new collection: an extra measure now, and effect sizes to plan the next study.
Re-analysis pilotWays to start
Pick a starting scope
Start from recordings you already hold or from baseline in a new study. The fee and timeline are fixed in writing before any data moves.
Re‑analysis of a trial you already ran
Lowest-risk startReadings on your scale, rater flags and an effect‑size estimate for your next trial, from audio you already hold. No new collection.
Prospective study
Trial QC
Pre-screening
New to speech? Start with recordings your trials already hold; your primary endpoint and visit schedule stay as they are ›
Already using a speech vendor? A second reading and a stability audit; your vendor stays in place ›
Running your own speech models? Named features; your own measures recalibrated when phones change ›
News and resources
What’s new at Cephalgo
Our methods are presented at scientific meetings on neurology, CNS trials and digital biomarkers. White papers on Alzheimer’s, Parkinson’s, Huntington’s and ALS are available on request from our research page.